The Long Game by Mehdi Yacoubi

Share this post
The Long Game 57: Alcohol Consumption & Aging, Friendships, Bioprinting Organs, Long Term Thinking
thelonggame.xyz

The Long Game 57: Alcohol Consumption & Aging, Friendships, Bioprinting Organs, Long Term Thinking

šŸ“£ Vital Pre-Seed Round, What You Do is Who You Are, Advice, The Machine, Failure, Clay, and Much More!

Mehdi Yacoubi
Jun 13, 2021
8
Share this post
The Long Game 57: Alcohol Consumption & Aging, Friendships, Bioprinting Organs, Long Term Thinking
thelonggame.xyz

Hi there, it’s Mehdi Yacoubi, co-founder at Vital, and this is The Long Game Newsletter. To receive it in your inbox each week, subscribe here:


šŸ“£ Announcement: I’m very excited to announce Vital’s pre-seed round led by Samuel Gil and with great angel investors, including Balaji Srinivasan, Qiao Wang, Kenneth Schlenker, Robert Miller, Gonz Sanchez, Adam Gries, Robert Lufkin, MD, Ilan Benhaim, and many more!

Twitter avatar for @Mehdiyac
Mehdi Yacoubi @Mehdiyac
Very excited to announce @joinvital pre-seed round led by @samuelgil & w/ great angels incl. @balajis @QwQiao @kschlenker @bertcmiller @gonsanchezs @adamgries @robertlufkinmd & many more. At Vital, we are making health optimization easy & enjoyable. šŸ§µšŸ‘‡ joinvitalhealth.com
joinvitalhealth.comVital - Longer and Healthier Lives Through Metabolic Health Optimization.Vital believes in prevention and optimization. Through powerful bio-tracking, data-informed recommendations, and science-based learnings, Vital helps people get and stay healthy.
3:39 PM āˆ™ Jun 8, 2021
169Likes17Retweets

šŸ“£ We are hiring (all the openings):

  • Product Designer

  • Senior Frontend Engineer

  • Junior Frontend Engineer

If you know the right people for this journey, please let me know. We’re offering $1,000 in Bitcoin if you refer a candidate we end up hiring.


In this episode, we explore:

  • Alcohol consumption and aging

  • Friendships

  • Understanding the assumption stack of your mentors

  • What You Do is Who You Are

  • Printing organs

Let’s dive in!


šŸ„‘ Health

šŸŗ Alcohol Consumption and Aging

Here’s an unfortunate study for those who enjoy a cold beer or a glass of wine. It shows that alcohol consumption accelerates aging.

Epigenetic age acceleration is considered a measure of biological aging based on genome-wide patterns of DNA methylation. Although age acceleration has been associated with incidence of diseases and death, less is known about how it is related to lifestyle behaviors.

Among 2,316 women, we evaluate associations between self-reported alcohol consumption and various metrics of epigenetic age acceleration. Recent average alcohol consumption was defined as the mean number of drinks consumed per week within the past year; lifetime average consumption was estimated as the mean number of drinks per year drinking.

Whole blood genome-wide DNA methylation was measured with HumanMethylation450 BeadChips and used to assess four epigenetic clocks and their corresponding metrics of epigenetic age acceleration.

Although alcohol consumption showed little association with most age acceleration metrics, both lifetime and recent average consumption measures were positively associated with GrimAgeAccel.

In a mutually adjusted model, only average lifetime alcohol consumption remained associated with GrimAgeAccel.

Although alcohol use does not appear to be strongly associated with biological age measured by most epigenetic clocks, lifetime average consumption is associated with higher biological age assessed by the GrimAge epigenetic clock.

On this topic, I’ve been following the growth of the non-alcoholic or low-alcoholic alternatives as I believe it will be the future. Fitt Insider had a great issue about it.

In 2019, alcoholic beverage sales in the US surpassed $250B.

But there’s a catch:Ā 43%Ā of drinking-age Americans don’t consume alcohol. And 40% say they’re drinking less than they did five years ago.

Driving this trend,Ā 66%Ā of US millennials said they’re making efforts to reduce their alcohol consumption, citing motivating factors like well-being and weight loss. A sign of what’s to come,Ā Gen ZĀ is consumingĀ less alcoholĀ than previous generations.

Globally, the World Health Organization expects the proportion of drinkers to fall by 1.4 percentage points toĀ 40.3%Ā between 2020 to 2025.

Twitter avatar for @jwmares
Justin Mares @jwmares
I'm seeing a big shift in friends moving away from: - alcohol - caffeine - nicotine and towards - cannabis - psychedelics We don't want our parents' drugs.
3:43 PM āˆ™ Apr 6, 2021
4,341Likes283Retweets

🌱 Wellness

šŸ™ On Friendship

A beautiful read on friendship, good friendships, bad friendships, and more.

These are the friendships that fill our souls, and bolster and shape our identities and life paths. They have also been squeezed into social science labs enough times for us to know that they keep us mentally and physically healthy: good friends improveĀ immunity, sparkĀ creativity, drop ourĀ blood pressure, ward off dementia among theĀ elderly, and even decrease our chances ofĀ dyingĀ at any given time. If you feel you can’t live without your friends, you’re not being melodramatic.

But even our easiest and richest friendships can be laced with tensions and conflicts, as are most human relationships. They can lose a bit of their magic and fail to regain it, or even fade out altogether for tragic reasons, or no reason at all. Then there are the not-so-easy friendships; increasingly difficult friendships; and bad, gut-wrenching, toxic friendships. The pleasures and benefits of good friends are abundant, but they come with a price. Friendship, looked at through a clear and wide lens, is far messier and more lopsided than it is often portrayed.


Share


🧠 Better Thinking

šŸ—Æ Understanding the Assumption Stack of your Mentors

I often come back to the idea that giving advice doesn’t really work in many cases. It’s a mix of a survivorship bias and giving advice to ourselves that we make universal when it should not.

While listening to Bryan Johnson last week, I really liked his perspective on advice. He explains:

Listen to advice and see it for what it is: a mirror of that person, and then map and know that your future is going to be in a zeroth-principle land. What you’re hearing today is a representation of what may have been the right principle to build upon previously, but they’re likely depreciating very fast. I’m a strong proponent that people ask for advice but they don’t take advice.

So how do you take advice? It’s in the careful examination of the advice. The person makes a statement about a given thing that we should follow. The value is not in doing that. The value is in understanding the assumption stack they built around that body of knowledge.

We tend to love ā€œrecipes,ā€ frameworks, and playbooks, but you can’t follow something blindly and expect it to work.

Twitter avatar for @abouelatta_ali
Ali Abouelatta @abouelatta_ali
Send me a startup advice, I'll send you a counter-example
11:30 PM āˆ™ May 31, 2021
2,931Likes634Retweets

āš”ļø Startup Stuff

šŸ’¼ What You Do is Who You Are

I read What You Do is Who You Are by Ben Horowitz over the last couple of weeks, and it’s a great read on company culture. At the time we’re starting to shape Vital’s culture, I enjoyed having the perspective of Ben Horowitz on this matter.

Here are a few notes on the book:

  • Every business owner and CEO knows the importance of workplace culture, even if they might struggle to define it. Creating the perfect environment for people to work in and making sure the whole company approaches work with the right attitude can be just as important—and just as hard—as developing the perfect product.

  • Culture isn’t the same as values—values are more like aspirations, while culture means something in practice. Culture varies a lot from one company to the next.

  • The example of Toussaint Louverture: the man who abolished slavery in Haiti. Through big decisions that clearly communicated values and culture, he was able to shape a special culture in his army. He understood that his decisions had to demonstrate his cultural priorities.

  • One idea I liked: using shocking rules. Amazon’s frugality, or starting every meeting 5 minutes in advance, are examples of this.

  • On acting right: when it comes to doing difficult things like delivering hard truths, why you do good isn’t as important as the simple fact that you do. Regardless of your motivations, it’s our actions that define us.

  • I loved the prison story of Shaka Senghor: while being the boss of a prison gang, he shaped a better culture through constant engagement.

  • The story of Uber is very interesting: the insane value put on competition led to very bad internal behavior.

  • On choosing the right virtues: it’s difficult to generalize because they have to come from you and your business. But there are some broad points you should consider. First, your new hires should embody these virtues. Then, the virtues should be actionable. Finally, your virtues should distinguish your company from the competition.

  • Culture is not static. It needs to be redefined when necessary. A wartime CEO has to place victory ahead of protocol on occasion and needs to act fast. A peacetime CEO focuses more on good protocol and longer-term success.

  • Trust and loyalty should be universally maintained.

Finally, always remember that staying calm is a superpower : )

Twitter avatar for @sama
Sam Altman @sama
Underrated and acquirable founder superpower: The ability to stay very calm while a hurricane of crises turns around you.
4:56 PM āˆ™ Jun 9, 2021
4,035Likes459Retweets

šŸ“š What I Read

šŸš‚ Why do we need to know about progress if we are concerned about the world’s large problems?

Another one from the great team at Our World in Data on why it’s important to focus on our biggest problems.

Progress means solving problems. This makes it necessary that anyone who wants to contribute to solutions needs to study both:

If you care about problems you need to study progress. The progress we achieved gives us the opportunity to learn how we solved problems in the past and – most fundamentally – to know that progress is possible.

If you want to make progress you need to study problems. Every problem we identify is an opportunity to make progress. To make the world a better place the first step is to understand the problems we are facing today.Ā 

⭐ Silicon Valley’s ā€˜Mission Protocol’ Revolution Is Beginning to Attain Critical Mass

On being a mission-focused company:

These entrepreneurs have always understood what so many progressives seem incapable of processing: building products that other people will buy requires not only hard work, talent, and a spirit of innovation, but also monomaniacalĀ focus.

šŸ›£ How to Do Long Term

Playing the long game is easier said than done—great piece by Morgan Housel detailing a few essential points.

Your belief in the long run isn’t enough. Your investors, coworkers, spouses, and friends have to sign up for the ride.


šŸŽ™ Podcast Episodes of the Week

Too many great episodes were released recently. It’s hard to catch up!

  • David Sinclair: Extending the Human Lifespan Beyond 100 Years

  • Dr. Peter Attia on Longevity Drugs, Alzheimer's Disease, and The 3 Most Important Levers to Pull


šŸ­ Brain Food

šŸ–Ø The Science Fiction World of 3D Printed Organs

What if we could print new organs for people who need them? This science-fiction concept is not so far from becoming a reality. Bioprinting could end up saving millions of people’s lives each year.

3D printingĀ holds the promise of changing the healthcare industry for the better by offering products such as smarter drugs and hyper-customized prosthetics. However, like something out of theĀ 1990 film Dark Man, in the near future, it might become commonplace for doctors to treat patients with printed organs. In fact, this is already happening. Researchers from various leading universities have 3D-printed functioning human organs. This could help to address the shortages of donor organs around the world, and especially in the United States.

This is an incredible perspective because the demand for organs is very high, and an organ transplant is extremely costly.

For example, according to the National Foundation for Transplants, a standard kidney transplant, on average, costs upwards ofĀ $300,000, whereas a 3D bioprinter, the printer used to create 3D printed organs, can cost as little asĀ $10,000Ā and costs are expected to drop further as the technology evolves over the coming years.

The technology is far from being perfect today, but it will improve with time.

To print an organ, scientists need to deposit cells specific to the organ they are building. For example, to create a liver, they would start with hepatocytes — the primary liver cells — as well as other supporting cells. As the cells are printed and accumulate on the platform, they are embedded in a microgel support matrix (or scaffold) and assume the shape of the organ. Scientists could also start with a bioink (a suspension of living cells) consisting ofĀ stem cells, which can differentiate into the desired target cells.


šŸŽ„ What I’m Watching

šŸ¤– The Machine

What if people could renounce their life permanently for a virtual life inside a machine? Pursuit of Wonder is very clairvoyant when it comes to understanding the challenges we might face in the future.

šŸ“œ The Story of Atrium

Our failures teach us more than our successes. This is a very interesting video where Justin Kan shares his introspection into why Atrium failed.


šŸ”§ The Tool of the Week

šŸ‘„ Clay—Be More Thoughtful with the People in Your Network

I’ve been looking for the perfect personal & professional CRM for a while. I haven’t found it yet. There are many great tools, but nothing works well with my existing setup. I remember this piece about how Peter Boyce organizes his social connections on Airtable; he does it masterfully. I’m much less organized than this!

This week I found this cool tool: Clay. I haven’t tried it yet, but it looks beautiful, a little bit like Superhuman for CRM.


🪐 Quote I'm Pondering

Infinite players cannot say when their game began, nor do they care. They do not care for the reason that their game is not bounded by time. Indeed, the only purpose of the game is to prevent it from coming to an end, to keep everyone in play.

— James Carse


If you enjoyed this newsletter, make sure to subscribe if you haven’t šŸ‘‡


šŸ‘‹ EndNote

Thanks for reading!

If you likeĀ The Long Game, please shareĀ it on social media or forward this email to someone who might enjoy it.Ā Podcast reviewsĀ are also gratefully received. You can also ā€œlikeā€ this newsletter by clicking the heart just below this, which helps me get visibility on Substack.

Share

Feel free to email me or find me onĀ TwitterĀ if you have any feedback or questions.

Until next week,

Mehdi Yacoubi

PS: Lots of newsletters get stuck in Gmail’s Promotions tab. If you find it in there, please help train the algorithm by dragging it to Primary. It makes a big difference.

Leave a comment

Share this post
The Long Game 57: Alcohol Consumption & Aging, Friendships, Bioprinting Organs, Long Term Thinking
thelonggame.xyz
Comments
TopNewCommunity

No posts

Ready for more?

Ā© 2023 Mehdi Yacoubi
Privacy āˆ™ Terms āˆ™ Collection notice
Start WritingGet the app
SubstackĀ is the home for great writing